Cartrophen Vet is given by injection to treat degenerative joint disease or arthritis in dogs. It has been found that it provides relief from pain, stiffness and lameness as effectively as the non-steroidal anti-inflammatory drugs commonly used in veterinary medicine. Normally a course of 4 injections is given at 5-7 day intervals. The beneficial effects are normally noticed after the second or third injection. The improvement usually continues until after the last injection is given, and then this is usually maintained for a few months after the fourth injection. If some deterioration is noted in future, the course can be repeated, of some vets will give a single injection once per month to help maintain the beneficial effects.
Please Note: Cartrophen Vet Injection does not come with a syringe or needle. To obtain these items separately, click here.
Cartrophen Vet contains Pentosan Polysulphate Sodium which is a semi-synthetic polymer. It has anti-inflammatory properties which particularly affect the cartilage within synovial joints. Cartrophen modifies the metabolism of the cartilage and the production of the lubricating synovial fluid. Cartrophen influences the underlying disease processes occurring in arthritis, reducing pain and helping regenerate damaged joint components.
Cartrophen is not recommended for young, growing dogs or for pregnant bitches. Cartrophen is sometimes prescribed by vets for use in horses. (It is exactly the same product which is used in both species.)
Previously it was recommended that Cartrophen should be stored at fridge temperatures. The manufacturer has now updated the storage information so that cold storage is not required. It is now recommended that Cartrophen is not stored above 25°C and that once the first dose has been used, the remainder is used or discarded within three months. Cartrophen is no longer shipped in a cold pack. Cartrophen will continue to be supplied in old packaging for a while which shows the old storage instructions. However the new requirements are as per the datasheet below. The official datasheet can also be viewed at www.noahcompendium.co.uk.
A clear colourless to slightly yellow aqueous solution for subcutaneous administration. Each ml contains:
100 mg Pentosan Polysulphate Sodium
0.01 ml Benzyl Alcohol
Pentosan Polysulphate Sodium is a semi-synthetic polymer with a mean molecular weight of 4000 Daltons, with anti-inflammatory activity, and modulating effects on cartilage and synovial metabolism and an affinity for cartilage. In addition, it has fibrinolytic, lipolytic and mild anti-coagulant activities.
Cartrophen Vet is indicated for the treatment of lameness and pain of degenerative joint disease/osteoarthrosis (non-infectious arthrosis) in the skeletally mature dog.
3 mg Pentosan Polysulphate Sodium/kg bodyweight on four occasions, with an interval of 5–7 days between each administration.
By aseptic subcutaneous injection only of 0.3 ml Cartrophen Vet/10 kg bodyweight. An appropriately graduated syringe must be used to allow accurate administration of the required dose volume.
Cartrophen Vet is contra-indicated for the treatment of septic arthritis. In this case, appropriate antimicrobial therapy should be instigated.
Do not use in dogs with advanced liver or kidney impairment, or evidence of infection.
Do not use in dogs with blood disorders, coagulation disorders, bleeding or malignancy (especially haemangiosarcoma). Pentosan polysulfate has an anticoagulant effect.
Do not use during the peri-operative period.
Do not use in the skeletally immature dog (ie dogs whose long bone growth plates have not closed).
A clinical effect may not be observed until after the second injection of the course of treatment.
Dogs should be weighed prior to administration to ensure accurate dosing.
Use with caution in dogs with history of pulmonary lacerations. Caution is also recommended in cases of hepatic impairment.
No more than 3 courses of 4 injections should be administered in a 12 month period.
Laboratory studies in rabbits showed embryotoxic effects associated with a primary effect on the parent at repeated daily doses 2.5 times the recommended therapeutic dose.
The safety of the product in the pregnant bitch has not been studied, therefore use is not recommended in these circumstances.
The product should not be used at the time of parturition due to its anticoagulant effects.
NSAIDs and in particular aspirin should not be used in combination with pentosan polysulfate sodium as they may affect thrombocyte adhesion and potentiate the anticoagulant activity of the product. Corticosteroids have been shown to be antagonistic to a number of actions of pentosan polysulfate sodium. Furthermore, use of anti-inflammatory drugs may result in a premature increase in the dog's activity, which may interfere with the therapeutic activity of the product.
Do not use concurrently with steroids or non-steroidal anti-inflammatory drugs, including aspirin and phenylbutazone.
Do not use concurrently with heparin, warfarin or other anti-coagulants.
Do not exceed the standard dose. Increasing the recommended dose may result in exacerbation of stiffness and discomfort.
Do not store above 25°C. Keep container in the outer carton in order to protect from light. Keep out of the reach of children.
Following withdrawal of the first dose, use the product within 3 months. Discard unused material. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
When the container is broached (opened) for the first time, using the in-use shelf life which is specified on this package insert, the date on which any product remaining in the container should be discarded should be worked out. The discard date should be written in the space provided on the carton.
Normal precautions should be observed. Care should be taken to avoid accidental self-injection. Wash splashes from eyes and skin immediately with water. Wash hands after use.
Multidose vials of 10 ml.
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