Caninsulin is derived from porcine insulin, which is chemically identical to the insulin found in dogs. It has an intermediate period of activity, meaning that it can suit once or twice daily treatment regimes for diabetes mellitus. It is important that your vet performs the appropriate blood tests and tailors a treatment protocol which suits your individual dog or cat.
It is important to note that the concentration of Caninsulin is different from all other types of insulin available on the market. (This was done to make it easier to give the smaller doses often needed compared with human treatments.) This means that only Caninsulin syringes are suitable for use with Caninsulin (calibrated at 40 international units per ml) and human syringes (calibrated at 100 international units per ml) should not be used because they will not give the stated dose. Caninsulin can be given by conventional syringe and needle, or using the Caninsulin Vetpen which takes 2.7ml cartridges and single use, disposable needles. For more information on treatment, see below:
The basic rules for successful treatment of diabetes mellitus in dogs and cats revolve around correct, consistent feeding and a regular, consistent daily routine. Suitable diets are lower in carbohydrate and higher in fat and protein than many commercial diets. An animal on a once-daily injection of insulin should receive about one third of the daily food ration at the same time as the injection, then the main meal of the day should be given to coincide with the peak activity of that injection, which is usually about 8 hours later. Animals on twice daily injections can be fed more evenly through the day which tends to suit cats much better. Dogs and cats show a very poor response to the tablets used for some types of diabetes in people (the oral hypoglycaemics) and so insulin injections every day are the only real option.
If the amount of insulin given is too low, then your dog or cat will have an excessive thirst and may lose weight. There will also be a significant risk of other problems, such blindness. (Due to diabetic cataracts in dogs, or diabetic retinopathy in cats.) If too much insulin is given, your pet will feel unwell and might well suffer a hypoglycaemic episode (a "hypo") which can cause weakness, staggering and trembling, occasionally leading to fitting, coma and even and death. (If this is happening, it can quickly be rectified by giving a little glucose or honey by mouth.) DO NOT give extra insulin! Hence It is important to have regular blood tests to monitor how well treatment is working. With care it is usually possible to treat dogs or cats very successfully for years. It is also interesting to note that a fair proportion of cats will only suffer from diabetes temporarily, and spontaneous recovery does sometimes happen. Recovered cats no longer require insulin injections, as long as they are maintained on a suitable diet. Caninsulin is not licensed for use in cats, but there are currently no licensed treatments for diabetes in cats. Caninsulin is found by vets to work very well in cats.
How to use Caninsulin VetPen:
VetPen Starket Kit includes:
- Caninsulin Vetpen: Caninsulin delivery device, available in two sizes: 0.5-8IU (0.5 unit dose increments) and 1-16IU (1 unit dose increments)
- Quick Pen Components Guide: Simple, illustrated diagram that shows Caninsulin VetPen components and accessories
- Client Instruction Booklet: Easy-to-follow, step-by-step instructions with photos that show clients how to load, use and store the pen
- Needles: 28 VetPen needles to get you started
- Needle Remover: Device that allows for safe removal of needles from the pen
- Handling Adapters: Release button extension and dose selector adaptor to enhance user handling
- Travel Pouch: Flexible pouch holds pen, needles, sharps remover adaptors and insulin.
- Product Price QTY
Caninsulin Insulin » Bottle » 2.5ml x 10Estimated dispatch within 24 working hours. TVP: £92.30 Our price: £45.75 Buy
Caninsulin Insulin » Bottle » 2.5mlEstimated dispatch within 24 working hours. TVP: £9.23 Our price: £4.58 Buy
Caninsulin Insulin » Bottle » 10mlEstimated dispatch within 24 working hours. TVP: £33.05 Our price: £13.25 Buy
Caninsulin Insulin » Syringes 0.5ml » Box of 30Estimated dispatch within 24 working hours. TVP: £17.42 Our price: £11.06 Buy
Caninsulin Insulin » Syringes 1ml » Box of 30Estimated dispatch within 24 working hours. TVP: £17.42 Our price: £11.31 Buy
Caninsulin Insulin » Vetpen Cartridges » 10x 2.7mlEstimated dispatch within 24 working hours. TVP: £119.06 Our price: £49.39 Buy
Caninsulin Insulin » Vetpen Needles x 100Estimated dispatch within 24 working hours. TVP: £51.72 Our price: £27.50 Buy
Caninsulin Insulin » Vetpen Starter Pack » 0.5 to 8iuEstimated dispatch within 24 working hours. TVP: £93.53 Our price: £47.63 Buy
Caninsulin Insulin » Vetpen Starter Pack » 1 to 16iuEstimated dispatch within 24 working hours. TVP: £93.53 Our price: £48.02 Buy
- Qualitative and quantitative composition
- Pharmaceutical form
- Clinical particulars
- Pharmacological particulars
- Pharmaceutical particulars
- Marketing Authorisation Holder (if different from distributor)
- Date of the first authorisation or date of renewal
- Date of revision of the text
- Any other information
- Legal category
Qualitative and quantitative composition
Each ml contains: Insulin*40 IU.
*(Porcine insulin present as approximately 30% amorphous Zinc insulin and 70 % crystalline Zinc insulin in a suspension). Preservative: methylparahydroxybenzoate 0.1 % w/v.
For full list of excipients, see section Pharmaceutical Particulars.
White to nearly white suspension for injection.
Dogs and cats.
Indications for use
The product is an intermediate acting insulin product containing porcine insulin, which is structurally identical to canine insulin. It is indicated in cases of diabetes mellitus (insulin deficiency) in dogs and cats, where the required blood levels are achieved by using an individually adjusted dose of the product.
The product must not be administered by the intravenous route. The product is a medium duration insulin and is not intended for the treatment of animals with severe acute diabetes presenting in a ketoacidotic state.
Special warnings for each target species
In the cat diabetic remission is possible.
Special precautions for use
Before the product is administered owners should be instructed to have a box of powdered glucose at home. Signs of hunger, increasing anxiety, unstable locomotion, muscle twitching, stumbling or sinking in the rear legs and disorientation indicate progression of hypoglycaemia and requires immediate administration of glucose solution and food to restore blood glucose levels.
Polyuria, polydipsia and polyphagia in combination in chronic cases with weight loss, general bad condition, loss of hair or abnormal furry coat and lethargy are the most common clinical symptoms of hyperglycaemia and require administration of insulin to restore blood glucose levels to the normal range.
The use of progestagens (oestrus inhibitors) in patients suffering from diabetes mellitus should be avoided. Stress and irregular extra exercise must be avoided. Care must be taken with the use of corticosteroids. Ovariohysterectomy may have to be considered.
It is important to establish a strict feeding schedule in consultation with the owner which will include a minimum of fluctuations and changes. Administration of the product must be carried out by an adult responsible for the welfare of the animal.
The product must be administered with specific 40IU sterile single-use syringes (vial) or with VetPen (cartridge).
Accidental self-injection can provoke clinical signs of hypoglycaemia and there is a low possibility of an allergic reaction. In case of accidental self-injection seek medical advice immediately and show the package insert to the doctor. In the unlikely event or accidental eye and skin contact, wash the area with clean, running water.
Local injection site reactions have been reported rarely in dogs and very rarely in cats. These reactions are usually mild and reversible. In very rare cases, allergic reactions to porcine insulin have been reported.
Use during pregnancy, lactation or lay
The use of the product is not contra-indicated during pregnancy or lactation but requires close veterinary supervision to account for changes in metabolic requirements during this period.
Changes in insulin requirements may result from administration of substances which alter glucose tolerance, such as corticosteroids, thiazide diuretics, progestogens, amitraz and alpha-2 agonists, such as medetomidine, dexmedetomidine, xylazine. Monitoring of glucose concentrations should be used to adjust the dose accordingly. Similarly, changes in diet or exercise may alter insulin requirements.
Amounts to be administered and administration route
Caninsulin should be administered once or twice daily, as appropriate, by subcutaneous injection. Alternate the injection site daily. Shake the vial thoroughly until a homogeneous, uniformly milky suspension is obtained. Foam on the surface of the suspension formed during shaking should be allowed to disperse before the product is used and, if required, the product should be gently mixed to maintain a homogeneous, uniformly milky suspension before use. Agglomerates can form in insulin suspensions: do not use the product if visible agglomerates persist after shaking thoroughly.
Vial: Invert the vial a few times before use until a homogenous suspension is obtained. A 40 IU/ml insulin syringe should be used.
Cartridge: The cartridge is designed to be used with VetPen. VetPen is accompanied by a package leaflet with detailed instruction for use to be followed. The injection procedure when using VetPen is as follows:
•Peel the protective film from a new pen needle. Screw the pen needle straight onto the cartridge holder. Remove the outer protective needle cap from the pen needle. Replace the pen cap onto the insulin pen. Turn the pen up and down at least 10 times.
•It is important to prime the pen before use to avoid injection of air and ensure proper dosing. Dial one unit on the dose selector. Remove the pen cap. Hold the pen with the needle pointing up. Tap the cartridge gently with your finger a few times to push any air bubbles to the top of the cartridge. Push and hold the release button towards the needle until the arrow (>) on the pen body points to the starting line (-) on the dose selector. Repeat until a drop of insulin appears at the needle tip. The insulin pen is now ready for use.
•Make sure the arrow (>) on the pen body points to the start line (-) on the dose selector.
•Dial up the number of units required per your veterinarian’s direction.
•The injection should be performed subcutaneously, 2 to 5 cm (3/4 to 2 in) from the dorsal midline, varying from behind the scapulae to the mid-lumbar region and alternating sides. Insert the needle using the injection technique recommended by your veterinarian then push the release button towards the pen needle and hold it in place until the start line on the dose selector returns to the arrow on the pen body (>-). Count to a minimum of 5 seconds before removing the needle from the skin.
If the dose selector stops before the start line (-) returns to the arrow (>), this indicates that your pet has not received a full dose.
If only a partial dose is administered, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection. If your pet dislodges the needle before the count of 5, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection. When changing between dosing devices (syringes or VetPen), owners should be advised to monitor their animal closely to detect any changes in behaviour or clinical condition. A dose adjustment may be required. A once daily injection is sufficient to reduce the blood glucose concentration in most diabetic dogs. However, the duration of action may vary, making it necessary to administer the insulin dose twice daily to some diabetic dogs. In diabetic cats, it is necessary to administer Caninsulin twice daily. The dose depends on the degree of deficit in the animal's own insulin production and is therefore different in each case.
Dog: Insulin therapy is initiated with the starting dose of 0.5 to 1.0 IU/kg body weight once daily, rounded down to the lowest entire number of units. Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose by approximately 10% according to the evolution of the diabetes clinical signs and to the results of serial blood glucose measurement. Alterations in dose should not normally be made more frequently than every 3 days.
The duration of insulin action as determined by blood glucose curve, may require treatment to be administered twice daily. In such cases, the dose per injection must be decreased by 25% so that the total daily dose is less than doubled. For example for a 10 kg dog receiving 5 IU once daily, the new dose (rounded down to the nearest whole unit) would be 3 IU per injection initially. The new doses should be administered at 12-hour intervals. Further dose adjustments should be made progressively as previously explained. Following switching to twice daily dosing, it is recommended that the clinical signs and blood glucose response be monitored closely. To achieve a balance between the generation of glucose and the effect of the product, feeding should be synchronized with the treatment and the daily ration divided into two meals. The composition and quantity of the daily food intake should be constant. In dogs treated once daily, the second meal is usually fed at the time of peak insulin effect. In dogs treated twice daily, feeding coincides with Caninsulin administration. Each meal should be fed at the same time each day.
Cat:The initial dose is 1 IU or 2 IU per injection based on the baseline blood glucose concentration, as presented in the following table. Cats require twice daily administration.
Cat blood glucose concentration
Starting dose per cat
<20 mmol/l or < 3.6 g/l (<360 mg/dl)
1 IU twice daily
≥20 mmol/l or ≥ 3.6 g/l (≥360 mg/dl)
2 IU twice daily
The starting dose should not exceed 2 IU per injection. The composition and quantity of the daily food intake should be constant. Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose according to the results of serial blood glucose measurement. Alterations in dose should not normally be made more frequently than every week. Increments of 1 IU per injection are recommended. Due to the day-to-day variation in the blood glucose response, and the variations in insulin responsiveness that are seen with time, larger or more frequent increases in dose are not recommended.
Maintenance phase in dogs and cats
Once the maintenance dose has been reached and the animal is stabilised, a long term management program needs to be established. The aim should be to manage the animal in such a way as to minimize the variations in its insulin requirement. This includes clinical monitoring to detect under or over dosage of insulin and adjustment of dose if required. Careful stabilization and monitoring will help to limit the chronic problems associated with diabetes, including cataracts (dogs), fatty liver (dogs and cats), etc. Follow up examinations should be performed every 2-4 months (or more often if there are problems) to monitor the animal’s health, the owners records and biochemical parameters (like blood glucose and/or fructosamine concentration). Adjustments to the insulin dose should be made based on interpretation of the clinical signs supported by the laboratory results. Somogyi overswing, also called rebound hyperglycaemia, is a response to an overdose of insulin insufficient to cause, potentially fatal, hypoglycaemia. As hypoglycaemia begins to develop, a hormonal response is triggered which results in the release of glucose from hepatic glycogen stores. This results in rebound hyperglycaemia which may also manifest as glycosuria for part of the 24-hour cycle. There is a danger that the Somogyi overswing is interpreted as a requirement for increase in the insulin dose rather than a decrease.This can be avoided by basing decisions on serial blood glucose measurements rather than single point measurements. The ability of pet owners to recognize the signs of hypo- or hyperglycaemia and respond appropriately is very important.
Before the product is administered owners should be instructed to have a box of powdered glucose at home. Signs of hunger, increasing anxiety, unstable locomotion, muscle twitching, stumbling or sinking in the rear legs and disorientation indicate progression of hypoglycaemia and require immediate administration of glucose solution and food to restore blood glucose levels.
ATC Vet Code QA10AC03. Pharmacotherapeutic group Drugs used in Diabetes and Analogues for injection, intermediate-acting, Insulin (pork).
The active ingredient highly purified porcine insulin is a naturally occurring hormone produced by the pancreas by the beta cells in the Islets of Langerhans. The overall effect of insulin is to promote an anabolic state in which there is a net synthesis of carbohydrate, protein and fat. Insulin facilitates the intake of glucose obtained from food or gluconeogenesis by cells that are in need of energy supply for metabolism. Liver, adipose tissue and brain in particular utilise large amounts of glucose. In diabetes mellitus there is a decreased use of glucose caused by a relative or absolute insulin deficiency. Entrance of glucose into cells is therefore inhibited and glucose accumulates in the body fluids. In diabetic dogs, the action of Caninsulin in blood glucose concentrations, following subcutaneous administration peaks at about 4-8 hours post-injection and lasts for 14-24 hours. In diabetic cats the action of Caninsulin on blood glucose concentrations after subcutaneous administration peaks at about 4-6 hours and last for 8-12 hours post injection. The product is an intermediate acting product containing 30% amorphous insulin, which exerts an effect at about 3 hours after subcutaneous injection and has a duration of effect of about 6-8 hours, and 70% crystalline insulin which has a slower onset and a maximum effect between 7-12 hours after injection and a duration of 16-24 hours.
Methylparahydroxybenzoate 0.1 % w/v, Zinc chloride, Sodium acetate trihydrate, Sodium chloride, Hydrochloric acid or Sodium hydroxide (for pH adjustment) and Water for injections.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening of the immediate packaging: 28 days.
Special precautions for storage
Store upright and refrigerated between + 2°C and + 8°C. Protect from light. Do not freeze. After first opening store refrigerated at between + 2°C and + 8°C or not above 25°C.
Carton with 5 or 10 glass vials (Ph.Eur. Type I) of 2.5 ml with a rubber stopper and aluminium cap, or a carton with 1 glass vial (Ph.Eur. Type I) of 10 ml with a rubber stopper and aluminium cap. 2.7 ml glass Type I cartridge with two sterile colourless Type I glass beads 2.4-2.5 mm in diameter. Closed with a red, 10 mm bromobutyl rubber plunger on the bottom, and with a gold coloured, 7.5 mm bi-layer bromobutyl rubber/polyisoprene stopper and an aluminium crim cap on top. Available in cartons of 10 x 2.7 ml cartridges. The glass cartridge is designed to be used with the injector VetPen 8 or VetPen 16. Not all pack sizes may be marketed.
Any unused product or waste materials should be disposed of in accordance with national requirements.
Marketing Authorisation Holder (if different from distributor)
Date of the first authorisation or date of renewal
8 December 1992.
Date of revision of the text
Any other information
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All prices include VAT where applicable.
Summary of Customer Ratings & Reviews for Caninsulin Insulin
- Ease Of Use
- Value For Money
- Absence Of Side Effects
1 out of 1 (100%) customers would recommend this product.
Have you tried this product? Write a review and help others!
Caninsulin12th May 2013
- VioVet Customer Since: September 2011
- From: Norfolk, United Kingdom
- Pet's Name: Misty
- Species: Dog
- Breed: Border Terrier
This is a necessity for the well being of my dog, Misty. It always arrives extremely well packaged and next day delivery, and is kept cool with ice bags. As it is a prescription drug it is cheaper to get this from Viovet rather than from the Vet even after paying for a prescription. Great Service.
- Ease Of Use
- Value For Money
- Absence Of Side Effects
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