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Accidental human injection
should be avoided, with extra care taken with women of child-bearing age. Due to the oily nature of this injection, it is important for the
operator to avoid accidental injection into a human finger, as the
resulting reaction can potentially lead to loss of the finger. Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication. Introduction 
Company name: Virbac Limited
Address: Woolpit Business Park
Windmill Avenue
Woolpit
Bury St Edmunds
Suffolk
IP30 9UP
Telephone: 01359 243243
Fax: 01359 243200
Website: www.virbac.co.uk
Presentation
A pale yellow injectable solution containing 30mg/ml aglepristone.
Uses
For the termination of pregnancy in bitches up to 45 days from mating.
Dosage and administration
Administer 10mg per kg bodyweight aglepristone by subcutaneous injection only, equivalent to 0.33ml Alizin, twice, 24 hours apart. Refer to table below.
Weight of bitch
| 3kg
| 7kg
| 10kg
| 15kg
| 20kg
| 30kg
| 40kg
| Volume of Alizin
| 1ml
| 2.3ml
| 3.3ml
| 5ml
| 6.6ml
| 10ml
| 13.3ml
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Light massage of the injection site is recommended after administration.
Contra-indications, warnings, etc
For animal treatment only. Nor-steroids are used in humans to induce abortion. Accidental injection may be a particular hazard to women who are pregnant, intending to become pregnant or whose pregnancy status is unknown. Care should be taken by the veterinary surgeon when handling the product and the person restraining the dog to AVOID ACCIDENTAL SELF-INJECTION. This is an oil-based product that may cause prolonged local reactions at the site of injection. In case of accidental injection seek urgent medical advice and show the doctor this warning.
Not to be used in animals with known hypersensitivity to the active ingredient.
Keep out of the reach of children.
In bitches confirmed as pregnant, a partial abortion may occur in up to 5% of cases; owners should be warned to this effect. A clinical examination (uterine palpation) is always recommended 10 days after treatment and at least 30 days after mating in order to confirm termination of pregnancy.
The administration of Alizin may produce transient pain at the injection site; any local inflammation produced is also resolves uneventfully.
In bitches treated beyond the twentieth day of gestation, abortion may be accompanied by the physiological signs of parturition, i.e. foetal expulsion, slight anorexia and mammary congestion.
After induced abortion with Alizin an early return to oestrus is frequently observed (the oestrus to oestrus interval may be shortened by one to three months).
Pharmaceutical precautions
Protect from light.
Store below 25°C.
Following withdrawal of the first dose, use the product within 28 days.
Dispose of empty containers and unused product in accordance with local safety regulations.
Legal category
POM-V
Packaging Quantities
Glass vials of 5 and 10ml.
Further information
Aglepristone is a synthetic steroid having antiprogestagenic activity by competing with progesterone at the level of progesterone receptors. In vitro studies have shown that Aglepristone has an affinity for these receptors three times greater than progesterone.
The administration of three times the recommended dose in bitches produced no adverse effects other than inflammation caused by the large volume of injection.
Marketing authorisation number
Vm 5653/4108.
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