Advantage Flea Control

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Advantage is one of the most effective and safe treatments to treat fleas on dogs, cats and rabbits.

Available as a spot on, it is easy to apply and treats the whole animal (apart from dogs weighing over 25kg). Advantage can be used on cats and dogs from 8 weeks of age, and on rabbits from 10 weeks. It is safe to apply to lactating females and doing this will treat the puppies or kittens as well as the adult.

In addition to this flea treatment you may require an additional household spray to combat fleas which may not have yet hatched or dormant fleas in and around the house. Please click here to see the range of household sprays available.

Click here for an alternative product

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Filter the products displayed:
  • Product Price QTY  
  • 40 For Small Cats, Dogs & Rabbits » Pack Of 4 Pipettes
    Estimated dispatch within 24 working hours.
    RRP: £19.54 Our price: £11.53 Buy
  • 80 For Large Cats & Pet Rabbits » Pack Of 4 Pipettes
    Estimated dispatch within 24 working hours.
    RRP: £20.36 Our price: £12.01 Buy
  • 100 For Medium Dogs 4-10kg » Pack Of 4 Pipettes
    Estimated dispatch within 24 working hours.
    RRP: £20.83 Our price: £12.33 Buy
  • 250 For Large Dogs 10-25kg » Pack Of 4 Pipettes
    Estimated dispatch within 24 working hours.
    RRP: £21.41 Our price: £12.78 Buy
  • 400 For Extra Large Dogs Over 25kg » Pack Of 4 Pipettes
    Estimated dispatch within 24 working hours.
    RRP: £21.66 Our price: £12.89 Buy

Presentation

A clear yellow to slightly brownish solution containing as active substance imidacloprid. Each tube contains 0.4 ml (40 mg imidacloprid), 0.8 ml (80 mg imidacloprid), 1 ml (100 mg imidacloprid), 2.5 ml (250 mg imidacloprid) and 4.0 ml (400 mg imidacloprid) respectively as listed above. The product also contains benzyl alcohol and butylhydroxytoluene (E321) as an antioxidant.

Uses

For the prevention and treatment of flea infestations on cats and dogs, and for the treatment of biting lice (Trichodectes canis) on dogs.

For the treatment of flea infestations on pet rabbits.

Fleas are killed within one day following treatment. One treatment prevents further flea infestation for up to four weeks on dogs, three to four weeks on cats and up to one week on pet rabbits. The product can be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD) in the cat and the dog, where this has been previously diagnosed by a veterinary surgeon.

Dosage and administration

Please refer to Table 1

Dosage and Treatment Schedule

TABLE 1

Species

Product

No. of Pipettes

Imidacloprid (mg/kg bw)

Cats

Less than 4 kg bodyweight

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

1 x 0.4 ml

Minimum of 10

4 kg and greater

Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits

1 x 0.8 ml

Maximum of 20

Dogs

Less than 4 kg bodyweight

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

1 x 0.4 ml

Minimum of 10

4 kg to less than 10 kg

Advantage 100 Spot-On Solution for Dogs

1 x 1.0 ml

Minimum of 10

10 kg to less than 25 kg

Advantage 250 Spot-On Solution for Dogs

1 x 2.5 ml

Minimum of 10

25 kg to less than 40 kg

Advantage 400 Spot-On Solution for Dogs

1 x 4.0 ml

Minimum of 10

40 kg and greater

Advantage 400 Spot-On Solution for Dogs

2 x 4.0 ml

Minimum of 10

Rabbit

Adult less than 4 kg bodyweight (older than 10 weeks)

4 kg and greater

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits

1 x 0.4 ml 1x 0.8 ml

Minimum of 10 Maximum of 20

Treatment should be repeated after four weeks. Treatment of nursing bitches and queens controls flea infestations on both dam and offspring.

Fleas are killed within one day following treatment. One treatment prevents further flea infestation on dogs and cats for up to four weeks and on rabbits for up to one week. Should re-treatment be necessary earlier than four weeks, do not treat more frequently than weekly.

Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all cats, dogs and rabbits in the household are treated.

The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.

In the case of biting louse infestation in dogs, a veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.

Method of Administration

Remove one tube from the package. Hold the tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube. See Figure 1.

Advantage - Opening pipette

Figure 1: Opening a tube

Administration to the Cat/Rabbit

Part the hair on the pet’s neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 2. Correct application will minimise the opportunity for the animal to lick off the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

Advantage - Application to cat and rabbit

Figure 2: Administration to the cat/rabbit

For dogs of less than 25kg body weight

With the dog in the standing position, part the coat between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 3.

Advantage - Application to dog (1)

Figure 3: Administration to dogs up to 25kg

For dogs of 25 kg body weight and greater

The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 3 or 4 spots all located at different application sites along the dog's backline from the shoulder to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the tube on the skin and gently squeeze the tube to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animal's side. See Figure 4.

Advantage - Application to big dog (1)

Figure 4: Administration to dogs over 25kg

For all dogs

Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run down the side of the dog. The product is bitter tasting and salivation may occasionally occur if the dog licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimize the opportunity for the dog to lick the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

Use During Pregnancy and Lactation

No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far indicates that no adverse effects are to be expected in these animals.

Contra-indications, warnings, etc

Do not treat unweaned puppies or kittens of less than 8 weeks of age.

Do not use on pet rabbits of less than 10 weeks of age.

Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients.

Apply only to undamaged skin.

This product is for topical use and should not be administered orally.

Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the recipient animal.

Do not allow recently treated animals to groom each other.

For external use only.

The product is bitter tasting and salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within a few minutes without treatment (see dosage and administration).

On very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation and disorientation has also been reported.

Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in dogs.

No incompatibility has been observed between this product at twice the recommended dose and the following commonly used veterinary products: fenthion, lufenuron, milbemycin, febantel, pyrantel and praziquantel (dogs) and lufenuron, pyrantel and praziquantel (cats).

The compatibility of the product was also demonstrated with a wide range of routine treatments under field conditions including vaccination.

In cats, no adverse clinical signs were produced using doses of five times the therapeutic level for eight consecutive weeks.

In dogs, no adverse clinical signs were produced by individual doses of up to 200 mg/kg body weight (five to eight times the therapeutic dose), daily treatments at 100 mg/kg body weight for five consecutive days or weekly treatments at five times the maximum dose rate for eight consecutive weeks.

In rabbits, no adverse clinical signs were seen using doses of up to 45 mg/kg body weight (4 times the therapeutic level) weekly for 4 consecutive weeks.

Dogs: In rare cases of overdose or licking of treated fur, nervous system disorders (such as twitching, tremors, ataxia, mydriasis, miosis, lethargy) can occur.

Poisoning following inadvertent oral uptake in either man or animals is unlikely. In this event, treatment should be symptomatic.

There is no known specific antidote but administration of activated charcoal may be beneficial.

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Withdrawal period(s)

Do not use on rabbits intended for human consumption.

User Safety

Wash hands thoroughly after use.

Wash off any skin contamination with soap and water.

After application do not stroke or groom animals until the application site is dry (typically within an hour or so). People with known skin sensitivity may be particularly sensitive to the product.

This product contains benzyl alcohol and may cause skin sensitisation or transient skin reactions (for example allergy, irritation, tingling).

Avoid contact between the product and the skin, eyes and mouth.

If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water.

If skin or eye irritation persists, seek medical attention. If the product is accidentally swallowed, obtain medical attention immediately.

Do not eat, drink or smoke during application.

Store away from food, drink or animal feeding stuffs.

Environmental Safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local / national requirements.

Pharmaceutical precautions

No special precautions for storage. Store away from food, drink and animal feeding stuffs.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years

Legal category

NFA-VPS

Packaging Quantities

Blister pack, containing 4 white polypropylene pipettes with caps, filled as follows:

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

4 x 0.4 ml pipettes

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

4 x 0.8 ml pipettes

Advantage 100 Spot-On Solution for Dogs

4 x 1.0 ml pipettes

Advantage 250 Spot-On Solution for Dogs

4 x 2.5 ml pipettes

Advantage 400 Spot-On Solution for Dogs

4 x 4.0 ml pipettes

Further information

Pharmacotherapeutic group: antiparasitic products, insecticides and repellents ATCvet code: QP53AX17 Imidacloprid, 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine is an ectoparasiticide belonging to a new group of chloronicotinyl compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine

Imidacloprid is an ectoparasiticide belonging to a group of chloronicotinyl compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine.

The pharmacological properties of imidacloprid are novel. The substance has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS). The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptor sites and the postulated poor penetration through the blood/brain barrier in mammals, it has virtually no effect on the mammalian CNS. The minimal pharmacological activity in mammals is supported by safety studies involving systemic administration of sub-lethal doses to rabbits, mice and rats.

In further studies, in addition to the adulticide flea efficacy of imidacloprid, a larvicidal flea efficacy in the surroundings of the treated cat or dog has been demonstrated. Larval stages in the cat’s and dog's surroundings are killed following contact with a treated animal. Oral studies in the rat show imidacloprid to be absorbed rapidly from the gastro-intestinal tract. Almost complete absorption (95%) occurs within 48 hours. Peak plasma concentrations are observed within 2.5 hours following administration. Tissue distribution is also rapid with the lowest levels recorded in the brain. The active ingredient undergoes extensive metabolism with only 10-16% remaining as parent compound. Almost complete (96%) elimination occurs within 48 hours, approximately 75% being removed by the kidneys and 21% with the faeces. The solution is indicated for cutaneous administration. Following topical application, the product is quickly distributed over the animal. Acute dermal studies in the rat and target animal overdose and serum kinetic studies have established that systemic absorption is very low, transient and not relevant for clinical efficacy. This has been further demonstrated by a study in which fleas were not killed after having fed on previously treated animals once the animal’s skin and fur had been cleaned of all active material.

Marketing authorisation number

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

Vm 00010/4117

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

Vm 00010/4134

Advantage 100 Spot-On Solution for Dogs

Vm 00010/4167

Advantage 250 Spot-On Solution for Dogs

Vm 00010/4166

Advantage 400 Spot-On Solution for Dogs

Vm 00010/4165

GTIN (Global Trade Item No)

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

04007221014676

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

04007221014713

Advantage 100 Spot-On Solution for Dogs

04007221014645

Advantage 250 Spot-On Solution for Dogs

04007221014652

Advantage 400 Spot-On Solution for Dogs

04007221014669

Need help or advice? Contact us:

  • Freephone: 0800 084 2608
  • Mon - Fri: 8:30am - 7:00pm
  • Sat: 10:00am - 3:00pm
  • Email: support@viovet.co.uk

All prices include VAT where applicable.

Summary of Customer Ratings & Reviews for Advantage Flea Control

Overall Rating:
4.8 out of 5
  • Effectiveness
    4.6 out of 5
  • Ease Of Use
    4.6 out of 5
  • Value For Money
    4.4 out of 5
  • Absence Of Side Effects
    4.8 out of 5

5 out of 5 (100%) customers would recommend this product.

5 stars
4 reviews
4 stars
1 reviews
3 stars
0 reviews
2 stars
0 reviews
1 star
0 reviews

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Write a Review!
5 out of 5

Advantage 100

21st May 2013
  • VioVet Customer Since: April 2013
  • From: Somerset, United Kingdom

Very good easy to use would recommend this

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Alan Cocksedge would recommend this to a friend!
Number of people who found this review helpful:
4 out of 5

Works when Frontline or others dont!

13th May 2013
  • VioVet Customer Since: June 2012
  • From: Bristol, United Kingdom

After many years of using Frontline without any problems all the fleas on my pets suddenly seemed to develop an immunity to it, making it almost completely ineffective! I was seeing an increasing population of fleas alive and well on my pets 7 days after applying which clearly wasnt right. Despite all sorts of efforts with hoovering. shampoos and flea sprays the easiest and most simple fix of all to our problems was to use advantage which wiped out all of the fleas again with no trace. If the fleas develop an immunity to advantage then I will start to worry!

  • Effectiveness
    5 out of 5
  • Ease Of Use
    3 out of 5
  • Value For Money
    3 out of 5
  • Absence Of Side Effects
    4 out of 5
DPH would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Good Value Treatment for Fleas

7th May 2013
  • VioVet Customer Since: November 2012
  • From: West Sussex, United Kingdom

This is the first time I have used Avantage flea control for my dog. The four pipettes provided in the pack are very good value and extremely easy to use. One pipette a month makes it easy to remember when to use.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Gillian Hammond would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

No more pills!

7th May 2013
  • VioVet Customer Since: April 2013
  • From: Rutland, United Kingdom

I was using capstar and drontal on my cat and dog for fear of them ingesting the spoton but they are both becoming very stubborn with tablets. Advantage is very easy to use and after keeping them seperate for a day they are fine. The best thing is that the wormer is included which makes life so much easier. Can't tell how effective it is as it's only been a few days but no problems so far

  • Effectiveness
    3 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    4 out of 5
  • Absence Of Side Effects
    5 out of 5
Tammy would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Great Value - does the job!

7th May 2013
  • VioVet Customer Since: November 2008
  • From: Essex, United Kingdom

This is often on special offer so that you can get 12 months worth of treatment for a super low price. Great for multiple cat households as it makes it a lot cheaper. Great results, we have no fleas and no manic scratching going on!

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Kackers Richardson would recommend this to a friend!
Number of people who found this review helpful:
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Ask your own question about Advantage Flea Control





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Questions & Answers for Advantage Flea Control

Below are some recent questions we've received regarding Advantage Flea Control, including answers from our team.

Blood stream or topical 17th Mar 2014

Does this product enter the blood stream the way that advocate does or is it purely topical?

John Cousins
  • Veterinary Surgeon at VioVet

Advantage is a purely topical treatment. Absorption through the skin into the blood stream is almost non-existent and has no significant effect. This is in contrast the the similarly named product Advocate (from the same manufacturer) which is absorbed very well through the skin (and works on internal parasites too). Advantage is only active against parasites on the skin or in contact with debris from the skin (which includes flea larvae in bedding etc).

Small or large for my cats 27th Aug 2013

  • VioVet Customer Since: July 2013
  • From: East Sussex, United Kingdom

Hello,
One of my cats is 4.5kg and the other is 5.5kg.
Do I need to purchase the small or large pack?

Thanks
Charlotte

  • Product Management Team at VioVet

You would need to get Advantage 80 which is the correct dose for both your cats.