Activyl Spot-on is the latest flea treatment for dogs and cats made by MSD. Fleas have shown no resistance to this innovative product which has a totally unique active ingredient, called indoxacarb. Activyl is supplied in pipettes of two different sizes for cats and five different sizes for dogs, so that each animal receives just the right dose for its bodyweight. One pipette is used per month to maintain effective flea control on puppies and kittens from 8 weeks of age..
Activyl is the first product designed to achieve flea control through the use of "metabolic activation, or bioactivation". It is applied once every month to the surface of the skin where fleas take it up and they then convert it into a highly active metabolite. The drug in Activyl has very little effect without the activation until it is taken in by a flea or other insect, so the possibility of toxicity to the base ingredient is very slim. Mammals are not able to activate the compound in this way and so are not exposed to the active insecticide by licking at their coat or swallowing hair - unlike other spot-on treatments.
Each ml contains 195 mg indoxacarb.
Each unit dose pipette delivers:
Unit dose (ml)
Activyl spot-on solution for very small dogs
Activyl spot-on solution for small dogs
Activyl spot-on solution for medium dogs
Activyl spot-on solution for large dogs
Activyl spot-on solution for extra large dogs
Activyl spot-on solution for small cats
Activyl spot-on solution for large cats
Excipients: Isopropyl alcohol 354 mg/ml.
For a full list of excipients, see Section "Pharmaceutical Particulars".
Spot-on solution. A clear, colourless to yellow solution.
Dogs and cats
For dogs and cats: Treatment and prevention of flea infestation (Ctenocephalides felis).The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). Developing stages of fleas in the pet’s immediate surroundings are killed following contact with Activyl treated pets.
The safety of Activyl has not been established in dogs and cats younger than 8 weeks of age.
The safety of Activyl has not been established in dogs weighing less than 1.5 kg and in cats weighing less than 0.6 kg.
Care should be taken to apply the dose to an area where the animal cannot lick it off, as described under Amounts to be administered and administration route, and to ensure that animals do not groom each other immediately following treatment. Care should be taken to ensure that the content of the pipette or the applied dose does not come into contact with the eyes of the recipient and/or other animals. The product remains effective following shampoo treatment, water immersion (swimming, bathing) and exposure to sunlight. However, animals should not be allowed to swim or treated with shampoo within 48 hours after treatment.
Do not eat, drink or smoke while handling the veterinary medicinal product. The sachet is child-resistant. Keep the product in the sachet until use, in order to prevent children from getting direct access to the product. Keep the used pipette out of reach and sight of children. Wash hands immediately after use. This product contains indoxacarb. People with known hypersensitivity to indoxacarb should not use this product. As the veterinary medicinal product may cause moderate eye irritation, avoid contact with eyes. If this occurs, rinse slowly and gently with water. This product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition.
A brief period of hypersalivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimise licking of the application site.Transitory scratching or hair loss at the application site may occur.These effects will usually resolve without treatment.
The application of the veterinary medicinal product may produce a local, temporary oily appearance or hair clumping at the application site. A dry white residue may be also observed. This is normal and will generally resolve within a couple of days after administration. These changes do not affect the safety or efficacy of the veterinary product.
Do not use in pregnant or lactating animals or in animals intended for breeding.
Dogs: The recommended dose is 15 mg indoxacarb/kg bodyweight, equivalent to 0.077 ml/kg bodyweight. The following table defines the size of pipette to be used according to the weight of the dog:
Weight of Dog (kg)
Pipette size to be used
Activyl Spot-on-Solution for very small dogs
Min. of 15
6.6 - 10
Activyl Spot-on solution for small dogs
10.1 - 20
Activyl Spot-on solution for medium dogs
20.1 - 40
Activyl Spot-on solution for large dogs
40.1 - 60
Activyl Spot-on solution for very large dogs
> 60 kg
The appropriate combination of pipettes should be used.
Cats: The recommended dose is 25 mg indoxacarb/kg bodyweight, equivalent to 0.128 ml/kg bodyweight. The following table defines the size of pipette to be used according to the weight of the cat:
Weight of Cat (kg)
Pipette size to be used
Activyl Spot-on solution for small cats
Minimum of 25
Activyl Spot-on solution for large cats
Maximum of 50
Method of administration: For spot-on use only. Open one sachet and remove the pipette.
Step 1: The animal should be standing for easy application. With one hand, hold pipette in an upright position away from your face and with the other hand, snap tip open by bending it and folding it back on itself.
Step 2: Part the hair until the skin is visible and place pipette tip against the skin between the shoulder blades for dogs, or at the base of the skull for cats. Squeeze pipette firmly applying the entire contents directly to the skin.
In larger dogs, the entire contents of the pipette(s) should be applied evenly to two or three or four spots, all located at different application sites along the backline from the shoulder to the base of the tail. Do not apply an excessive amount of solution at any one spot which could cause some of the solution to run off the side of the animal.
Treatment schedule: Following a single administration, the veterinary medicinal product will prevent further flea infestation for at least 4 weeks.
No adverse effects were observed in dogs and cats aged 8 weeks or older administered 5 times the recommended dose on 8 occasions at 4 weeks intervals or administered 5 times the recommended dose on 6 occasions at 2 weeks intervals.
ATC Vet Code QP53AX27
Pharmacotherapeutic group Pharmacotherapeutic group: Ectoparasiticides for topical use.
Indoxacarb is an ectoparasiticide belonging to the oxadiazine chemical family. After being converted into a metabolite, indoxacarb is active against adult, larval and egg stages of insects. In fleas, in addition to its adulticidal activity, indoxacarb activity on the developing larval stages in the immediate surroundings of the treated pet has been demonstrated. Indoxacarb is a pro-drug that requires bioactivation by the insect enzymes to exert its pharmacodynamic effects. It enters the insect primarily through ingestion but is also absorbed, to a lesser degree, through the insect cuticle. In the mid-gut of susceptible insect species, the insect’s enzymes remove the carbomethoxy group from parent indoxacarb, and convert it into its biologically active form.The bioactivated metabolite acts as a voltage-dependent sodium channel antagonist in insects, by blocking the sodium channels that regulate the flow of sodium ions in the insect’s nervous system. This results in a rapid cessation of feeding within 0 to 4 hours after treatment followed by cessation of egg laying (oviposition), paralysis and death occurring within 4 to 48 hours.
Following a single spot-on application of the product, indoxacarb can still be detected in both skin and hair coat after 4 weeks post-treatment. Absorption through the skin also occurs, but this systemic absorption is partial and not relevant for the clinical efficacy. The absorbed indoxacarb is extensively metabolised by the liver to a variety of metabolites. The major route of excretion is in faeces.
Triacetin, Ethyl acetoacetate and Isopropyl alcohol.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
This veterinary medicinal product does not require any special temperature storage conditions. Store in the original package, in order to protect from moisture.
Cardboard box of 1 or 4 spot-on applicators, consisting of 0.51, 0.77, 1.03, 1.54, 3.08 and 4.62 ml pipettes. One size only per box. The pipette consists of a blister film (polypropylene/cyclic-olefin-copolymer/polypropylene) and a foil lidstock (aluminium/polypropylene co-extruded) sealed into aluminium sachets. Not all pack sizes may be marketed.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Activyl should not be allowed to enter surface waters as indoxacarb may have harmful effects on aquatic organisms.
Intervet International BV, Wim de Körverstraat 35 , 5831 AN Boxmeer, The Netherlands.
Activyl 100 mg spot-on solution for very small dogs
Activyl 100 mg spot-on solution for small dogs
Activyl 100 mg spot-on solution for medium dogs
Activyl 100 mg spot-on solution for large dogs
Activyl 100 mg spot-on solution for extra large dogs
Activyl 100 mg spot-on solution for small cats
Activyl 100 mg spot-on solution for large cats
18 February 2011.
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