Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication. Introduction 
Company name: Novartis Animal Health UK Ltd
Address: Frimley Business Park
Frimley
Camberley
Surrey
GU16 7SR
Telephone: 01276 694402
Fax: 01276 694403
Presentation
ACP Tablets 10 mg are pale yellow in colour and contain Acepromazine Maleate BP (Vet) equivalent to 10 mg acepromazine base. ACP Tablets 25 mg are pale yellow in colour and contain Acepromazine Maleate BP (Vet) equivalent to 25 mg acepromazine base.
Uses
The tablets are intended for use only in cats and dogs.
Anaesthetic premedication
Following acepromazine administration, the amount of anaesthetic necessary to induce anaesthesia is considerably reduced. This reduction is approximately one-third of a suitable induction agent.
Tranquillisation
Acepromazine tranquillisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis or marked sedation. This is achieved with low doses of acepromazine.
Sedation
At higher dose rates acepromazine is a sedative.
Travel sickness
A dose of 1 mg per kg given orally a quarter to half an hour before a light meal is effective in the prevention of travel sickness. Idiopathic vomiting may be controlled by acepromazine.
Acepromazine possesses anti-emetic, hypothermic, hypotensive and anti-spasmodic properties and shows a marked potentiating effect on barbiturate anaesthesia.
Dosage and administration
0.25–3 mg per kg bodyweight by oral administration. Onset of effects will be observed after 10–15 minutes. Normally single doses of acepromazine are administered. Long term use is not recommended.
Contra-indications, warnings, etc
Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic animals; rehydration should precede acepromazine administration.
In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur due to sinoatrial block caused by excessive vagal tone, and an attack may be precipitated by acepromazine. Where there is a history of this type of syncope, or if it is suspected because of excessive sinus arrhythmia, it may be advantageous to control the dysrhythmia with atropine given just before the acepromazine.
Large breeds
It has been noted that large breeds of dog are particularly sensitive to acepromazine and the minimum dose possible should be used in these breeds.
Overdosage
Slow intravenous injection of norepinephrine (noradrenaline) should be used whenever a hypertensive agent is required to reverse any fall in blood pressure.
Epinephrine (adrenaline) is contra-indicated in the treatment of acute hypotension produced by overdosage of acepromazine maleate, since further depression of systemic blood pressure can result. Other pressoramines such as norepinephrine or neosynephrine should be administered to reverse hypotensive effects. However, the reversing effect of norepinephrine is likely to be transient and repeated doses will normally be required.
Do not use in pregnant animals.
For animal treatment only.
Wash hands after use.
In the event of accidental ingestion seek medical advice taking this warning to show your doctor.
Use During pregnancy, lactation or lay
No formal studies on the safety of ACP Tablets in pregnant animals have been conducted.
Interaction with other medicinal products and other forms of interaction
Acepromazine is additive to the actions of other depressants and will potentiate general anaesthesia.
Pharmaceutical precautions
Do not store above 25°C. Protect from light. Keep out of reach of children.
Disposal
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Legal category
POM-V
Packaging Quantities
Containers of 500 × 10 mg or 25 mg tablets.
Further information Pharmacological Properties
Pharmacotherapeutic group: Antipsychotics
ATC vet code: QN05AA04
Pharmacodynamic Properties
Acepromazine is a phenothiazine. It is a central nervous system depressant with associated activity on the autonomic system. Phenothiazines have a central action due to inhibition of dopamine pathways, resulting in alteration of mood, reduction in fear and removal of learned or conditioned responses.
Acepromazine possesses anti-emetic, anti-convulsant, hypothermic, hypotensive and anti-spasmodic properties, and shows a marked potentiating effect of barbiturate anaesthesia.
Pharmacokinetic Particulars
The length of action of acepromazine appears to be prolonged and to be dose dependent.
PHARMACEUTICAL PARTICULARS
List of Excipients:
Lactose monohydrate
Maize starch
Pregelatinised starch
Povidine K29-32
Magnesium stearate
Shelf Life
Shelf life of veterinary medicinal product as packaged for sale: 4 years.
Marketing authorisation numbers
10 mg Tablets Vm 12501/4123
25 mg Tablets Vm 12501/4122
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